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sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity

Authors :
Pedro V. da Silva-Neto
Jonatan C. S. de Carvalho
Vinícius E. Pimentel
Malena M. Pérez
Diana M. Toro
Thais F. C. Fraga-Silva
Carlos A. Fuzo
Camilla N. S. Oliveira
Lilian C. Rodrigues
Jamille G. M. Argolo
Ingryd Carmona-Garcia
Nicola T. Neto
Camila O. S. Souza
Talita M. Fernandes
Victor A. F. Bastos
Augusto M. Degiovani
Leticia F. Constant
Fátima M. Ostini
Marley R. Feitosa
Rogerio S. Parra
Fernando C. Vilar
Gilberto G. Gaspar
José J. R. da Rocha
Omar Feres
Fabiani G. Frantz
Raquel F. Gerlach
Sandra R. Maruyama
Elisa M. S. Russo
Angelina L. Viana
Ana P. M. Fernandes
Isabel K. F. M. Santos
Vânia L. D. Bonato
Antonio L. Boechat
Adriana Malheiro
Ruxana T. Sadikot
Marcelo Dias-Baruffi
Cristina R. B. Cardoso
Lúcia H. Faccioli
Carlos A. Sorgi
on behalf of the IMUNOCOVID Study Group
Source :
Viruses, Vol 13, Iss 12, p 2521 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Uncontrolled inflammatory responses play a critical role in coronavirus disease (COVID-19). In this context, because the triggering-receptor expressed on myeloid cells-1 (TREM-1) is considered an intrinsic amplifier of inflammatory signals, this study investigated the role of soluble TREM-1 (sTREM-1) as a biomarker of the severity and mortality of COVID-19. Based on their clinical scores, we enrolled COVID-19 positive patients (n = 237) classified into mild, moderate, severe, and critical groups. Clinical data and patient characteristics were obtained from medical records, and their plasma inflammatory mediator profiles were evaluated with immunoassays. Plasma levels of sTREM-1 were significantly higher among patients with severe disease compared to all other groups. Additionally, levels of sTREM-1 showed a significant positive correlation with other inflammatory parameters, such as IL-6, IL-10, IL-8, and neutrophil counts, and a significant negative correlation was observed with lymphocyte counts. Most interestingly, sTREM-1 was found to be a strong predictive biomarker of the severity of COVID-19 and was related to the worst outcome and death. Systemic levels of sTREM-1 were significantly correlated with the expression of matrix metalloproteinases (MMP)-8, which can release TREM-1 from the surface of peripheral blood cells. Our findings indicated that quantification of sTREM-1 could be used as a predictive tool for disease outcome, thus improving the timing of clinical and pharmacological interventions in patients with COVID-19.

Details

Language :
English
ISSN :
19994915
Volume :
13
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Viruses
Publication Type :
Academic Journal
Accession number :
edsdoj.11ff9cf45f4e4d15bd09faff571b2561
Document Type :
article
Full Text :
https://doi.org/10.3390/v13122521