A Prospective Randomised Comparative Study on Use of Lignocaine with Zinc with Hydrocortisone Combination Ointment versus Lignocaine with Sucralfate with Metronidazole Combination Ointment in the Treatment of Acute Fissure in Ano

Background: An anal fissure is a cut or split in the epithelial lining of the anal canal distal to the dentate line. Various topical ointments been described for its treatment. Aim and Objectives: To study Lignocaine (3%) with Zinc (5%) with Hydrocortisone (0.25%) combination (LZH) ointment in comparison to Lignocaine (4%) with Sucralfate (7%) with Metronidazole (1%) combination (LSM) ointment with respect to pain relief, healing, patient satisfaction and safety in acute fissure in ano (AFIA). Material and Methods: This was a prospective randomized study. Sixty patients with AFIA were randomly divided into two groups of 30 patients each. In group A LZH ointment and in group B LSM ointment was prescribed and followed up weekly for six weeks. Results: Our study shows less pain score in group B as compared to group A. The rate of healing was statistically significantly better in group B from 3rd week onwards. The patient satisfaction score was better in group B (P value = 0.0004). No complication was seen in any patient. Conclusion: Our study shows that the LSM ointment in comparison to LZH ointment is associated with early pain relief, better healing, better overall patient satisfaction, and equally safe in patients with AFIA