Pooling analysis on prognostic value of PHH3 expression in cancer patients

Qian Hao,1,* Cong Dai,1,* Yujiao Deng,1,* Peng Xu,1 Tian Tian,1 Shuai Lin,1 Meng Wang,1 Kang Liu,1 Dingli Song,1 Ying Wu,1 Yan Guo,2 Zhijun Dai1 1Department of Oncology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, People’s Republic of China *These authors contributed equally to this work Background: Various studies have evaluated the significance of phospho-histone-H3 (PHH3) expression in cancer patients, but controversy over its reliability remains. We conducted a meta-analysis to summarize the prognostic relevance of PHH3 expression in cancer patients. Patients and methods: Nineteen studies, including 4803 patients, were identified by searching PubMed, Web of Science, Embase, and Cochrane Library. The correlation of PHH3 expression level with overall survival (OS), disease-free survival, and recurrence-free survival was analyzed. Results: Overall, the results suggest that high expression of PHH3 can predict a poor OS (HR=2.66, 95% CI=1.74–4.08, P