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Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers

Authors :
Wenpeng Zhang
Donghui Zhang
Qinhua Chen
Junhan Wu
Zheng Ouyang
Yu Xia
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

Mass spectrometry is widely used for large-scale lipid profiling but distinguishing unsaturated lipid isomers is still challenging. Here, the authors present an analytical platform for high-throughput identification of lipid C=C location isomers in clinical samples, showing that isomer ratios may guide biomarker discovery.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.119768cc75fc467688bcc0bb37a4c0c0
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-07963-8