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Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development

Authors :
Yi-Cheng Chang
Jan Manent
Jan Schroeder
Siew Fen Lisa Wong
Gabriel M. Hauswirth
Natalia A. Shylo
Emma L. Moore
Annita Achilleos
Victoria Garside
Jose M. Polo
Paul Trainor
Edwina McGlinn
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

The authors identify Nuclear receptor subfamily 6 group A member 1 (Nr6a1) as a master regulator of elongation, segmentation, patterning and lineage allocation specifically within the trunk region of the mouse, acting downstream of the major signals known to control vertebral column formation.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.117f96f9c40b48e6a5318dfb51a9856a
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-35303-4