Back to Search Start Over

CLINICAL MANAGEMENT OF LOCALIZED BCG ADVERSE EVENTS IN CHILDREN

Authors :
Thais das Neves Fraga MOREIRA
Maria Isabel de MORAES-PINTO
Beatriz Tavares COSTA-CARVALHO
Anete Sevciovic GRUMACH
Lily Yin WECKX
Source :
Revista do Instituto de Medicina Tropical de São Paulo, Vol 58, Iss 0
Publisher :
Universidade de São Paulo (USP).

Abstract

SUMMARY BCG adverse events (BCG-AE) are rare conditions with no well-established treatment. This study aims to describe clinical characteristics and outcome of localized BCG-AE. Children with BCG-AEs who were treated at the Reference Center for Special Immunobiologicals of the Federal University of São Paulo from 2009 to 2011 were included. Patients were followed monthly until 3 months after healing. One hundred and twenty-seven patients with localized BCG-AE were followed: 67 (52.7%) had suppurative lymphadenitis; 30 (23.6%) injection-site abscess; five (3.9%) had enlarged lymph node > 3 cm; four (3.1%) had ulcer > 1 cm; and one (0.8%) had a local bacterial infection. Five patients (3.9%) had more than one BCG-AE simultaneously. Fifteen patients (11.8%) had atypical manifestations: seven wart-like lesions; five BCG reactivations; two other dermatologic lesions and one with vasomotor phenomenon. Isoniazid was used in 96 patients with typical BCG-AE (85.7%) until lesion resolution which took place 3.1 months later (in median); the healing rate was 90.6%. Patients with atypical manifestations had an individual approach. Regarding the outcome, 105/112 patients with typical AE and 13/15 patients with atypical AE had resolution of BCG-AE. Localized BCG-AE caused by BCG Moreau RJ had positive outcome when treated with a short course of isoniazid. Atypical BCG-AE are not infrequent.

Details

Language :
English
ISSN :
16789946
Volume :
58
Database :
Directory of Open Access Journals
Journal :
Revista do Instituto de Medicina Tropical de São Paulo
Publication Type :
Academic Journal
Accession number :
edsdoj.1161e473d4bc428b9d6349f2651088e1
Document Type :
article
Full Text :
https://doi.org/10.1590/S1678-9946201658084