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Reversible epigenetic alterations regulate class I HLA loss in prostate cancer
- Source :
- Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- Loss of HLA-I gene expression in prostate cancer is associated with repressive chromatin states, which can be reversed by pharmacological DNMT and HDAC inhibition leading to increased activation of co-cultured tumor-specific CD8+ T-cells.
- Subjects :
- Biology (General)
QH301-705.5
Subjects
Details
- Language :
- English
- ISSN :
- 23993642
- Volume :
- 5
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Communications Biology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1153e9cc0b6a481e85909d4a3f28af7d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s42003-022-03843-6