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T lymphocytes development and aging

T lymphocytes development and aging

Authors :
Mao Lipeng
Luo Junhong
Chen Guobing
Source :
生物医学转化, Vol 4, Iss 2, Pp 42-49-56 (2023)
Publication Year :
2023
Publisher :
Lanzhou University Press, 2023.

Abstract

T lymphocytes, as a vital component of the adaptive immune system, play a crucial role in maintaining immune health. A thorough investigation of their maturation and aging processes is essential for achieving a comprehensive understanding of the immune system. In this review, we provide an overview of the developmental trajectory of various T cell subsets, encompassing not only the well-known naive, effector, memory subgroups and regulatory T cells, but also delving deeper into unconventional and distinct subgroups such as γδ T cells, mucosal-associated invariant T (MAIT) cells, and natural killer T (NKT) cells. We place particular emphasis on the myriad transformations these cells undergo during the aging process.The advent of single-cell technology in recent years has significantly advanced our understanding of the fundamental mechanisms underlying T cell development and aging. In conclusion, we highlight potential avenues for addressing the persistent challenges encountered in T cell maturation and aging research.

Details

Language :
Chinese
ISSN :
20968965
Volume :
4
Issue :
2
Database :
Directory of Open Access Journals
Journal :
生物医学转化
Publication Type :
Academic Journal
Accession number :
edsdoj.10ee3f1cce14f77a39e7468aa575eb9
Document Type :
article
Full Text :
https://doi.org/10.12287/j.issn.2096-8965.20230205