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Dynamic prediction of bleeding risk in thrombocytopenic preterm neonates
- Source :
- Haematologica, Vol 104, Iss 11 (2019)
- Publication Year :
- 2019
- Publisher :
- Ferrata Storti Foundation, 2019.
-
Abstract
- Over 75% of severely thrombocytopenic neonates receive platelet transfusions, though little evidence supports this practice, and only 10% develop major bleeding. In a recent randomized trial, giving platelet transfusions at a threshold platelet count of 50x109/L compared to a threshold of 25x109/L was associated with an increased risk of major bleeding or mortality. This finding highlights the need for improved and individualized guidelines on neonatal platelet transfusion, which require accurate prediction of bleeding risk. Therefore, the objective of this study was to develop a dynamic prediction model for major bleeding in thrombocytopenic preterm neonates. This model allows for calculation of bleeding risk at any time-point during the first week after the onset of severe thrombocytopenia. In this multicenter cohort study, we included neonates with a gestational age
- Subjects :
- Diseases of the blood and blood-forming organs
RC633-647.5
Subjects
Details
- Language :
- English
- ISSN :
- 03906078 and 15928721
- Volume :
- 104
- Issue :
- 11
- Database :
- Directory of Open Access Journals
- Journal :
- Haematologica
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.10e2bb69285243de8e1ef3c5ba0357d8
- Document Type :
- article
- Full Text :
- https://doi.org/10.3324/haematol.2018.208595