The Effect of Regular Aerobic Exercise with Garlic Extract on Heart Apoptosis Regulatory Factors in Chronic Kidney Disease

Objective: Physical activity and herbal medicine can inhabit apoptosis with two different mechanisms. The aim of this study was to assess the combined effect of regular aerobic exercise with garlic extract on heart apoptosis regulatory factors in aged rats with chronic kidney disease. Materials and Methods: In this experimental research, 42 aged male Wistar rats (48-52 weeks) were selected and divided into 6 groups: control, doxorubicin, doxorubicin-salin, doxorubicin- garlic, doxorubicin - exercise, doxorubicin -garlic-exercise (combined). Chronic kidney disease was induced by a single doxorubicin injection (8.5 mg/kg). Swimming training was programmed 3 days /week, 30 min/day for 8 weeks. Both the doxorubicin garlic and combined groups with garlic extract were administered by garlic gavage at a dose of 2.5 g/kg. The renal Bax and Bcl-2 levels were evaluated by ELIZA method. A one-way analysis of variance was used to data analysis (P-value