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Pneumococcal carriage, density, and co-colonization dynamics: A longitudinal study in Indonesian infants

Authors :
Chrysanti Murad
Eileen M. Dunne
Sunaryati Sudigdoadi
Eddy Fadlyana
Rodman Tarigan
Casey L. Pell
Emma Watts
Cattram D. Nguyen
Catherine Satzke
Jason Hinds
Mia Milanti Dewi
Meita Dhamayanti
Nanan Sekarwana
Kusnandi Rusmil
E. Kim Mulholland
Cissy Kartasasmita
Source :
International Journal of Infectious Diseases, Vol 86, Iss , Pp 73-81 (2019)
Publication Year :
2019
Publisher :
Elsevier, 2019.

Abstract

Objectives: Nasopharyngeal carriage of Streptococcus pneumoniae underpins disease development and transmission. This study was performed to examine pneumococcal carriage dynamics, including density and multiple serotype carriage, in Indonesian infants during the first year of life. Methods: Two hundred healthy infants were enrolled at 2 months of age. Eight nasopharyngeal swabs were collected from enrolment until 12 months of age. Pneumococci were detected using quantitative PCR and serotyped by microarray. Regression models assessed factors influencing pneumococcal carriage and density. Results: Eighty-five percent of infants carried pneumococci at least once during the study. The median age at first acquisition was 129 days (interquartile range 41–216 days). The median duration of carriage was longer for the first pneumococcal acquisition compared with subsequent acquisitions (151 days vs. 95 days, p

Details

Language :
English
ISSN :
12019712
Volume :
86
Issue :
73-81
Database :
Directory of Open Access Journals
Journal :
International Journal of Infectious Diseases
Publication Type :
Academic Journal
Accession number :
edsdoj.10bd22ea79924f1096fe401c04ccac21
Document Type :
article
Full Text :
https://doi.org/10.1016/j.ijid.2019.06.024