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Pneumococcal carriage, density, and co-colonization dynamics: A longitudinal study in Indonesian infants
- Source :
- International Journal of Infectious Diseases, Vol 86, Iss , Pp 73-81 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Objectives: Nasopharyngeal carriage of Streptococcus pneumoniae underpins disease development and transmission. This study was performed to examine pneumococcal carriage dynamics, including density and multiple serotype carriage, in Indonesian infants during the first year of life. Methods: Two hundred healthy infants were enrolled at 2 months of age. Eight nasopharyngeal swabs were collected from enrolment until 12 months of age. Pneumococci were detected using quantitative PCR and serotyped by microarray. Regression models assessed factors influencing pneumococcal carriage and density. Results: Eighty-five percent of infants carried pneumococci at least once during the study. The median age at first acquisition was 129 days (interquartile range 41–216 days). The median duration of carriage was longer for the first pneumococcal acquisition compared with subsequent acquisitions (151 days vs. 95 days, p
- Subjects :
- Infectious and parasitic diseases
RC109-216
Subjects
Details
- Language :
- English
- ISSN :
- 12019712
- Volume :
- 86
- Issue :
- 73-81
- Database :
- Directory of Open Access Journals
- Journal :
- International Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.10bd22ea79924f1096fe401c04ccac21
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.ijid.2019.06.024