Back to Search
Start Over
Deuterium Metabolic Imaging—Rediscovery of a Spectroscopic Tool
- Source :
- Metabolites, Vol 11, Iss 9, p 570 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- The growing demand for metabolism-specific imaging techniques has rekindled interest in Deuterium (2H) Metabolic Imaging (DMI), a robust method based on administration of a substrate (glucose, acetate, fumarate, etc.) labeled with the stable isotope of hydrogen and the observation of its metabolic fate in three-dimensions. This technique allows the investigation of multiple metabolic processes in both healthy and diseased states. Despite its low natural abundance, the short relaxation time of deuterium allows for rapid radiofrequency (RF) pulses without saturation and efficient image acquisition. In this review, we provide a comprehensive picture of the evolution of DMI over the course of recent decades, with a special focus on its potential clinical applications.
- Subjects :
- deuterium
imaging
spectroscopy
magnetic resonance
metabolism
Microbiology
QR1-502
Subjects
Details
- Language :
- English
- ISSN :
- 22181989
- Volume :
- 11
- Issue :
- 9
- Database :
- Directory of Open Access Journals
- Journal :
- Metabolites
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1068b0b8a955435bbde864bc43771bdd
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/metabo11090570