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Protection of renal damage by HMG-CoA inhibitors: A comparative study between atorvastatin and rosuvastatin
- Source :
- Iranian Journal of Basic Medical Sciences, Vol 23, Iss 2, Pp 206-213 (2020)
- Publication Year :
- 2020
- Publisher :
- Mashhad University of Medical Sciences, 2020.
-
Abstract
- Objective(s): Hypercholesterolemia is a common metabolic disorder in developing and developed countries and is associated with the increased rates of chronic kidney disease (CKD). Statin therapy could reduce cholesterol synthesis as well as progression of CKD. Diversity between statins causes variety in pharmacokinetics and pharmacodynamics and also their pleiotropic effects. In the present investigation we aimed to evaluate the protective potentials of both atorvastatin (Ator) (as lipid-soluble statin) and rosuvastatin (Ros) (as water-soluble statin) against renal histopathological damages in the high cholesterol diet induced hypercholesterolemic rats (HCDIHR).Materials and Methods: Serum lipid profile, oxidized low density lipoprotein (OX-LDL), malondialdehyde (MDA), urea and creatinine levels, as well as renal histopathology were evaluated.Results: While Ros acted better than Ator to reduce serum low density lipoprotein cholesterol (LDL-C) (PConclusion: The findings underline that the lipophilic Ator may performs better than Ros in attenuating renal damages in HCDIHR.
Details
- Language :
- English
- ISSN :
- 20083866 and 20083874
- Volume :
- 23
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Iranian Journal of Basic Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1067419fcd2f4c348f0d5b5c8a7262b0
- Document Type :
- article
- Full Text :
- https://doi.org/10.22038/ijbms.2019.38239.9080