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Transcranial sonography as a diagnostic tool for Parkinson's disease: a pilot study in the city of Rio de Janeiro, Brazil

Authors :
Rita de Cássia Leite Fernandes
Ana Lucia Zuma de Rosso
Maurice Borges Vincent
Kátia Silveira da Silva
Claudia Bonan
Nordeval Cavalcante Araújo
Daniela Berg
Source :
Arquivos de Neuro-Psiquiatria, Vol 69, Iss 6, Pp 892-895 (2011)
Publication Year :
2011
Publisher :
Academia Brasileira de Neurologia (ABNEURO), 2011.

Abstract

In Brazil there is no systematic study on Transcranial Sonography (TCS), a neuroimaging method that depicts echogenic deep brain structures using ultrasound. OBJECTIVE: To establish the percentage of subjects with permissive temporal windows and to address the ability of TCS of the substantia nigra (SN) to distinguish parkinsonian patients in a Brazilian sample. METHOD: We performed TCS using the Acuson X300 (Siemens, Germany) in 37 individuals: 23 with Parkinson's disease (PD) and 14 healthy controls. RESULTS: 10.8% of subjects had insufficient temporal acoustic bone windows. SN echogenic areas were larger in patients (mean±SD, 0.31±0.08cm²) compared to controls (mean±SD, 0.17±0.02cm²). TCS accurately identified 88.2% of PD patients. CONCLUSION: A large proportion of Brazilians seem to be eligible for TCS. An expressive number of PD patients could be diagnosed by TCS based on an expanded SN echogenic area. However, the current data is preliminary and must be corroborated by larger studies.

Details

Language :
English
ISSN :
16784227 and 0004282X
Volume :
69
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Arquivos de Neuro-Psiquiatria
Publication Type :
Academic Journal
Accession number :
edsdoj.104d4fe5fd58424b982935e9cbda7f5a
Document Type :
article
Full Text :
https://doi.org/10.1590/S0004-282X2011000700008