Effect of oral Tadalafil on endometrial thickness in patients receiving Clomiphene citrate for ovulation induction

Background: Adequate and optimum endometrial development is required for a successful pregnancy to occur. Clomiphene citrate is well known for its negative impact on endometrial thickness. The long-acting phosphodiesterase 5 inhibitor, Tadalafil, was shown to improve endometrial growth in patients under Clomiphene citrate stimulation. Objective: To study the effect of Tadalafil on the endometrial thickness in Clomiphene citrate stimulated cycles as compared to clomiphene citrate alone and human menopausal gonadotropins. Study design: A randomized controlled study. Setting was at the infertility clinic of Cytogenetic and Endoscopy Unit, Zagazig University Hospital. Material and methods: The study included 236 patients who underwent a single cycle of ovulation induction and timed intercourse. Patients were divided into 3 groups: Controlled ovarian stimulation was done in group A by Clomiphene Citrate alone, in group B by Clomiphene Citrate with addition of Tadalafil and in group C by Human Menopausal Gonadotropins. Results: As regard the number of cases who got pregnant, we found that there was a statistically significant difference (P