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IRF2 is a master regulator of human keratinocyte stem cell fate
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- Epidermal homeostasis requires long term stem cell function. Here, the authors apply transcriptional circuitry analysis based on integrated epigenomic profiling of primary human keratinocytes with high and low stem cell function to identify IRF2 as a negative regulator of stemness.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0f22070deb8646359f9b585b7f128992
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-12559-x