Back to Search
Start Over
Role of the PNPLA3 polymorphism rs738409 on silymarin + vitamin E response in subjects with non-alcoholic fatty liver disease
- Source :
- Revista Espanola de Enfermedades Digestivas, Vol 110, Iss 10, Pp 634-640 (2018)
- Publication Year :
- 2018
- Publisher :
- Aran Ediciones, 2018.
-
Abstract
- ABSTRACT Background: non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in developed countries. Lifestyle changes are the pillar of the treatment, although a pharmacological approach is sometimes required in the case of a failure to respond/adhere to the diet. Objective: the aim of this study was to evaluate the effect of silymarin and the influence of the patatin-like phospholipase domain-containing protein 3 (PNPLA3) variant on the response to treatment in patients with NAFLD in a pilot study. Methods: a total of 54 patients with a NAFLD proven biopsy were enrolled in an open prospective study and were treated with Eurosil 85(r) (silymarin + vitamin E) for six months. Biochemical parameters and cardiovascular risk factors (diabetes mellitus, dyslipidemia, hypertriglyceridemia, arterial hypertension and HOMA-IR > 2.5) were recorded before and after six months of treatment. Non-invasive indexes (fatty liver index, lipid accumulation product and NAFLD-fibrosis score) were also calculated. The rs738409 PNPLA3 gene polymorphism status was also determined. Results: significant statistical changes from baseline values after six months of treatment were observed in transaminases levels but not in non-invasive index markers. Twenty patients (37.1%) were G allele carriers and had a higher percentage of lobular inflammation and ballooning on the basal liver biopsy. Patients with the G allele had a smaller decrease in transaminases levels after treatment with silymarin + vitamin E than non-G-allele carriers. Conclusions: treatment with silymarin + vitamin E produced a decrease in transaminases after six months of treatment without an accompanying weight loss. PNPLA3 G-allele carriers responded poorly to the treatment.
Details
- Language :
- English, Spanish; Castilian
- ISSN :
- 11300108
- Volume :
- 110
- Issue :
- 10
- Database :
- Directory of Open Access Journals
- Journal :
- Revista Espanola de Enfermedades Digestivas
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0f1260c716043c4a338a80ed87cbe24
- Document Type :
- article
- Full Text :
- https://doi.org/10.17235/reed.2018.5602/2018