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A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model
- Source :
- eLife, Vol 4 (2015)
- Publication Year :
- 2015
- Publisher :
- eLife Sciences Publications Ltd, 2015.
-
Abstract
- Although pain is a common symptom of various diseases and disorders, its contribution to disease pathogenesis is not well understood. Here we show using murine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS), that pain induces EAE relapse. Mechanistic analysis showed that pain induction activates a sensory-sympathetic signal followed by a chemokine-mediated accumulation of MHC class II+CD11b+ cells that showed antigen-presentation activity at specific ventral vessels in the fifth lumbar cord of EAE-recovered mice. Following this accumulation, various immune cells including pathogenic CD4+ T cells recruited in the spinal cord in a manner dependent on a local chemokine inducer in endothelial cells, resulting in EAE relapse. Our results demonstrate that a pain-mediated neural signal can be transformed into an inflammation reaction at specific vessels to induce disease relapse, thus making this signal a potential therapeutic target.
Details
- Language :
- English
- ISSN :
- 2050084X
- Volume :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- eLife
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0ec4e6b57e8942279410c29febe81f79
- Document Type :
- article
- Full Text :
- https://doi.org/10.7554/eLife.08733