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Maternally inherited diabetes mellitus and deafness (MIDD): A case report and review of literature

Authors :
Prabhat K Agrawal
Nikhil Pursnani
Ashish Gautam
Akhil P Singh
Awadhesh K Singh
Source :
Journal of Diabetology, Vol 14, Iss 3, Pp 173-176 (2023)
Publication Year :
2023
Publisher :
Wolters Kluwer Medknow Publications, 2023.

Abstract

Maternally inherited diabetes and deafness (MIDD) is a rare subtype of diabetes with a prevalence of up to 1% globally but often missed if not suspected. We present a case of MIDD and a thorough review of the literature related to it. The phenotypic presentation of diabetes depends on heteroplasmy levels of m.3243A>G mutation of the individual patient. Patients with MIDD may have involvement of other organs such as eye, muscles, kidney, and heart. In our patient, along with diabetes and deafness, there was also an associated vision loss with a strong maternal inheritance of diabetes. A young male who presented with diabetic ketoacidosis (DKA) and hearing and vision impairment and on further diagnostic work up turned out to be a case of genetically confirmed (m.3243A>G mutation) MIDD. To the best of our knowledge, this should be the first case of MIDD presenting as DKA being reported from India.

Details

Language :
English
ISSN :
20787685
Volume :
14
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Journal of Diabetology
Publication Type :
Academic Journal
Accession number :
edsdoj.0e8144bf36a4277b26145b94a5ef64a
Document Type :
article
Full Text :
https://doi.org/10.4103/jod.jod_21_23