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Roles of mTOR in the Regulation of Pancreatic β-Cell Mass and Insulin Secretion
- Source :
- Biomolecules, Vol 12, Iss 5, p 614 (2022)
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- Pancreatic β-cells are the only type of cells that can control glycemic levels via insulin secretion. Thus, to explore the mechanisms underlying pancreatic β-cell failure, many reports have clarified the roles of important molecules, such as the mechanistic target of rapamycin (mTOR), which is a central regulator of metabolic and nutrient cues. Studies have uncovered the roles of mTOR in the function of β-cells and the progression of diabetes, and they suggest that mTOR has both positive and negative effects on pancreatic β-cells in the development of diabetes.
- Subjects :
- mTOR
pancreatic β-cell
autophagy
ER stress
insulin secretion
Microbiology
QR1-502
Subjects
Details
- Language :
- English
- ISSN :
- 2218273X
- Volume :
- 12
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- Biomolecules
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0e5a98fb9d5e437fa080836ec412d4af
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/biom12050614