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Cutting‐Edge Technology for Early Intervention in Myocardial Infarction: Portable Fingertips‐Based Immunobiosensor
- Source :
- Advanced Sensor Research, Vol 3, Iss 7, Pp n/a-n/a (2024)
- Publication Year :
- 2024
- Publisher :
- Wiley-VCH, 2024.
-
Abstract
- Abstract Early intervention in acute myocardial infarction can minimize myocardial damage and improve patient survival. Herein, a low‐cost device‐free portable immunobiosensing platform for flexible monitoring of immediate myocardial infarction is reported. CuS‐Pt nanofragments (CuS‐Pt NFs) with high photothermal conversion efficiency (≈26.41%) are synthesized by liquid‐phase polarity‐mediated synthesis. The CuS NFs are loaded in situ with platinum (Pt) nanoreactors using a solvothermal reduction strategy, which is employed to enhance the efficiency of gas production. The resulting CuS‐Pt nanocatalysts are encapsulated within liposomes for signal cascade amplification. Specifically, cardiac troponin I (cTn I), a target biomarker in serum, is captured on pre‐modified microtiter plates and formed into a classical sandwich model. The thermo‐chemically kinetically enhanced CuS‐Pt reactor is released through a one‐step chemical treatment and transferred to a closed gas generator. Under the excitation of a near‐infrared laser emitter, the internal pressure in the gas generator device increases with time and drives the carbon quantum dot solution in the connected hose. The moving distance shows a correlation with the target concentration. This work provides a new implementation for the development of low‐cost, efficient pressure immunosensors without the requirement of a readout device.
Details
- Language :
- English
- ISSN :
- 27511219
- Volume :
- 3
- Issue :
- 7
- Database :
- Directory of Open Access Journals
- Journal :
- Advanced Sensor Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0e5217d6793e4959b807a6e35ec3bb62
- Document Type :
- article
- Full Text :
- https://doi.org/10.1002/adsr.202300204