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Microencapsulation of Enriched Extracts of Two Satureja Species by Spray Drying, Evaluation of the Controlled Release Mechanism and Cytotoxicity
- Source :
- Pharmaceutical Sciences, Vol 28, Iss 1, Pp 145-155 (2022)
- Publication Year :
- 2022
- Publisher :
- Tabriz University of Medical Sciences, 2022.
-
Abstract
- Background: Phenolic compounds are one of the main groups of secondary metabolites responsible for multiple biological and pharmacological properties that play a vital role in improving human health quality. Encapsulation by spray dryer creates protection toward the phenolic compounds as an efficient way for increasing product performance. Method: The phenolic compounds of Satureja khuzistanica Jamzad (SKH) and S. rechingeri Jamzad (SRH) were enriched based on adsorbent resin column chromatography and the enrichment index was confirmed by HPLC-UV analysis. Gum Arabic, carboxylated chitosan, and pectin with the optimum percentage of 1% w/w used to encapsulate SKH and SRH by the spray drying technique. Result: Encapsulation yield was 38.18 – 59.00 %, particle size ranged 2.278 - 4.689 µm, and release time was between 4.08 - 82.08 min. The gum Arabic-based capsules showed the fastest and pectin-based revealed the slowest release time. The best statistical model explained a release mechanism was Korsmeyer model. Anomalous transport was observed from all formulas except SKH-gum Arabic (case-I transport), SKH-pectin, and SRH-carboxylated-chitosan (super case-II transport). The cytotoxic activity of encapsulate SKH’s revealed reducing the viability of AGS evaluated by the MTT compared with SRH’s. Conclusion: Encapsulation by spray drying has proven to be a promising technique to improve the bioavailability, release time, and mechanism of functional polyphenolic compounds as medicines, food supplements, and food additives.
Details
- Language :
- English
- ISSN :
- 23832886 and 44942818
- Volume :
- 28
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Pharmaceutical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0e4ddf93f4494281800fa9e597813197
- Document Type :
- article
- Full Text :
- https://doi.org/10.34172/PS.2021.54