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Antimicrobial effectiveness of polyhexamethylene biguanide on Enterococcus faecalis, Staphylococcus epidermidis and Candida albicans

Authors :
Ivana Medvedec Mikić
Livia Cigić
Darko Kero
Danijela Kalibović Govorko
Goranka Prpić Mehičić
Arjana Tambić Andrašević
Paris Simeon
Source :
Medicinski Glasnik, Vol 15, Iss 2, Pp 132-138 (2018)
Publication Year :
2018
Publisher :
Medical Association of Zenica-Doboj Canton, 2018.

Abstract

Aim To evaluate the antimicrobial activity of 0.2% polyhexamethilene biguanide (PHMB) in root canal models infected with Enterococcus faecalis, Candida albicans and Staphylococcus epidermidis. PHMB was compared in these tests with 2.5% NaOCl and 0.2% CHX. Methods Prepared models of 50 human root canals (n=50) were immerged in mixed, four- weeks old culture that consisted of E .faecalis, S. epidermidis and C. albicans. Roots were randomly divided into three groups: one with 30 (n=30) and two with 10 (n=10) samples. Samples were treated with polyhexamethylene biguanide (PHMB) (0.2%), sodium hypochlorite (NaOCl) (2.5%) and chlorhexidine (CHX) (0.2%), respectively. Root dentin was sampled before and after the tretment with these solutions. Colony- forming units (CFU) were counted to asses the antimicrobial effects of three solutions on viability of selected microrganisms in specimens before and after the treatment.T-test was used for comparison of results between specimens before and after the treatment, while Newman-Keuls test was used for pairwise comparison at p=0.05. Results The PHMB was significantly more efficient in reducing the number of all three tested microorganisms. NaOCl and CHX made only statistically significant (p

Details

Language :
English
ISSN :
18400132 and 18402445
Volume :
15
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Medicinski Glasnik
Publication Type :
Academic Journal
Accession number :
edsdoj.0e263258c8a64a95a137ee9b1a2626cd
Document Type :
article
Full Text :
https://doi.org/10.17392/959-18