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Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- Studies with patient derived xenografts are hampered by factors such as genetic variability and sample availability. Here, the authors generate a leukemia mouse model by lentiviral transduction of normal human cord blood and show an oncogenic role of HOXB genes.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0dc063f01a744a6691471a7f27cd84dc
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-10510-8