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Effects of valproic acid on transcript levels in neurotrophin signaling pathway in mice hippocampus according to the implementation period

Authors :
Gök Duygu Kurt
Erdoğan Füsun Ferda
Göl Mehmet Fatih
Taheri Serpil
Önal Müge Gülcihan
Şükranlı Zeynep Yılmaz
Güvenilir Ecma
Yora Samed
Source :
The EuroBiotech Journal, Vol 8, Iss 3, Pp 103-114 (2024)
Publication Year :
2024
Publisher :
Sciendo, 2024.

Abstract

Valproic acid (VPA), is an antiepileptic drug and it has been known for a long time that exposure to VPA in the fetal period causes many behavioral, cognitive, and structural disorders. In this study, we aimed to evaluate the effects of the implementation period of VPA during pregnancy on both behavioral tests and the expression of 45 key genes belonging to the neurotrophin signaling pathway.

Details

Language :
English
ISSN :
2564615X
Volume :
8
Issue :
3
Database :
Directory of Open Access Journals
Journal :
The EuroBiotech Journal
Publication Type :
Academic Journal
Accession number :
edsdoj.0d962ee4cce407f8dc62f615a383ed5
Document Type :
article
Full Text :
https://doi.org/10.2478/ebtj-2024-0010