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Meta-analyses identify DNA methylation associated with kidney function and damage

Authors :
Pascal Schlosser
Adrienne Tin
Pamela R. Matias-Garcia
Chris H. L. Thio
Roby Joehanes
Hongbo Liu
Antoine Weihs
Zhi Yu
Anselm Hoppmann
Franziska Grundner-Culemann
Josine L. Min
Adebowale A. Adeyemo
Charles Agyemang
Johan Ärnlöv
Nasir A. Aziz
Andrea Baccarelli
Murielle Bochud
Hermann Brenner
Monique M. B. Breteler
Cristian Carmeli
Layal Chaker
John C. Chambers
Shelley A. Cole
Josef Coresh
Tanguy Corre
Adolfo Correa
Simon R. Cox
Niek de Klein
Graciela E. Delgado
Arce Domingo-Relloso
Kai-Uwe Eckardt
Arif B. Ekici
Karlhans Endlich
Kathryn L. Evans
James S. Floyd
Myriam Fornage
Lude Franke
Eliza Fraszczyk
Xu Gao
Xīn Gào
Mohsen Ghanbari
Sahar Ghasemi
Christian Gieger
Philip Greenland
Megan L. Grove
Sarah E. Harris
Gibran Hemani
Peter Henneman
Christian Herder
Steve Horvath
Lifang Hou
Mikko A. Hurme
Shih-Jen Hwang
Marjo-Riitta Jarvelin
Sharon L. R. Kardia
Silva Kasela
Marcus E. Kleber
Wolfgang Koenig
Jaspal S. Kooner
Holly Kramer
Florian Kronenberg
Brigitte Kühnel
Terho Lehtimäki
Lars Lind
Dan Liu
Yongmei Liu
Donald M. Lloyd-Jones
Kurt Lohman
Stefan Lorkowski
Ake T. Lu
Riccardo E. Marioni
Winfried März
Daniel L. McCartney
Karlijn A. C. Meeks
Lili Milani
Pashupati P. Mishra
Matthias Nauck
Ana Navas-Acien
Christoph Nowak
Annette Peters
Holger Prokisch
Bruce M. Psaty
Olli T. Raitakari
Scott M. Ratliff
Alex P. Reiner
Sylvia E. Rosas
Ben Schöttker
Joel Schwartz
Sanaz Sedaghat
Jennifer A. Smith
Nona Sotoodehnia
Hannah R. Stocker
Silvia Stringhini
Johan Sundström
Brenton R. Swenson
Maria Tellez-Plaza
Joyce B. J. van Meurs
Jana V. van Vliet-Ostaptchouk
Andrea Venema
Niek Verweij
Rosie M. Walker
Matthias Wielscher
Juliane Winkelmann
Bruce H. R. Wolffenbuttel
Wei Zhao
Yinan Zheng
Estonian Biobank Research Team
Genetics of DNA Methylation Consortium
Marie Loh
Harold Snieder
Daniel Levy
Melanie Waldenberger
Katalin Susztak
Anna Köttgen
Alexander Teumer
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Many genetic loci have been identified to be associated with kidney disease, but the molecular mechanisms are not well understood. Here, the authors perform epigenome-wide association studies on kidney function measures to identify epigenetic marks and pathways involved in kidney function.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.0d948668b1d0481ab5f9d661584f9e5e
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-27234-3