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Dose sparing of induction dose of propofol by fentanyl and butorphanol: A comparison based on entropy analysis
- Source :
- Saudi Journal of Anaesthesia, Vol 7, Iss 2, Pp 128-133 (2013)
- Publication Year :
- 2013
- Publisher :
- Wolters Kluwer Medknow Publications, 2013.
-
Abstract
- Background: The induction dose of propofol is reduced with concomitant use of opioids as a result of a possible synergistic action. Aim and Objectives: The present study compared the effect of fentanyl and two doses of butorphanol pre-treatment on the induction dose of propofol, with specific emphasis on entropy. Methods: Three groups of 40 patients each, of the American Society of Anaesthesiologistsphysical status I and II, were randomized to receive fentanyl 2 μg/kg (Group F), butorphanol 20 μg/kg (Group B 20) or 40 μg/kg (Group B 40) as pre-treatment. Five minutes later, the degree of sedation was assessed by the observer′s assessment of alertness scale (OAA/S). Induction of anesthesia was done with propofol (30 mg/10 s) till the loss of response to verbal commands. Thereafter, rocuronium 1 mg/kg was administered and endotracheal intubation was performed 2 min later. OAA/S, propofol induction dose, heart rate, blood pressure, oxygen saturation and entropy (response and state) were compared in the three groups. Statistical Analysis: Data was analyzed using ANOVA test with posthoc significance, Kruskal-Wallis test, Chi-square test and Fischer exact test. A P
- Subjects :
- Butorphanol
entropy
fentanyl
propofol
Anesthesiology
RD78.3-87.3
Subjects
Details
- Language :
- English
- ISSN :
- 1658354X
- Volume :
- 7
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Saudi Journal of Anaesthesia
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0d859213901c49098621a0061da4c93b
- Document Type :
- article
- Full Text :
- https://doi.org/10.4103/1658-354X.114052