甲状腺功能亢进合并烟雾病发病机制的研究进展 Progress of Pathogenesis of Hyperthyroidism Complicated with Moyamoya Disease

烟雾病是一种以双侧颈内动脉末端及大脑前动脉、大脑中动脉起始部慢性进行性狭窄或闭塞为特征，并继发颅底异常血管网形成的脑血管疾病。甲状腺功能亢进继发烟雾病的发病机制尚不清楚，可能与甲状腺功能、免疫与炎症、遗传因素等有关。免疫和炎症相关的分子变化对血管内皮细胞和平滑肌细胞的影响，可能在颅内大动脉狭窄、闭塞和烟雾血管的形成中起着重要作用。本文对甲状腺功能亢进继发烟雾病的可能病理生理学机制、免疫与炎症、遗传因素等发病机制进行综述。 Abstract: Moyamoya disease is a kind of cerebrovascular disease characterized by chronic progressive stenosis or occlusion at the end of bilateral internal carotid arteries and the beginning of anterior cerebral arteries and middle cerebral arteries, followed by abnormal vascular network formation at the skull base. The pathogenesis of moyamoya disease secondary to hyperthyroidism is still unclear, and may be related to the thyroid function, immunity and inflammation, and genetic factors. The effects of immunity and inflammation related molecular changes on vascular endothelial cells and smooth muscle cells, may play a key role in the formation of moyamoya vessels and large intracranial artery stenosis and occlusion. This paper summarized the pathogenesis of moyamoya disease secondary to hyperthyroidism by reviewing the available literature.