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Calcified Granulomatous Pneumocystis Jirovecii Pneumonia in a Toddler with Severe Combined Immunodeficiency—A Case Report

Authors :
Floriana Zennaro
Nagua Giurici
Natalia Maximova
Source :
Transplantology, Vol 3, Iss 4, Pp 283-287 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Pneumocysis jirovecii pneumonia (PJP) is a type of pneumonia originating from the fungus Pneumocystis jiroveci and is a major cause of serious pneumonia in immunocompromised conditions. PJP typically appears as bilateral diffuse pulmonary infiltrates. Granulomatous PJP is an uncommon form of pneumocystis infection, occurring in only 3% to 5% of patients. Calcification is exceptional. We present a 9-month-old boy affected by Severe Combined Immunodeficiency (SCID) that has been diagnosed at the age of 7 months following a lung Pneumocystis jirovecii infection. He underwent a routine total-body magnetic resonance imaging (MRI) prior to an allogeneic hematopoietic stem cell transplantation (HSCT). The MRI showed significant alterations of the pulmonary parenchyma; hence, a computer tomography of the lung was performed showing the presence of 11 calcified granulomatous nodules. We report a unique case of calcified granulomatous PJP in a toddler affected by SCID. Awareness of this rare yet possible presentation in patients with SCID is important given the potential clinical implications when managing a patient undergoing HSCT and it further enhances the importance of advanced radiologic imaging prior to HSCT.

Details

Language :
English
ISSN :
26733943
Volume :
3
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Transplantology
Publication Type :
Academic Journal
Accession number :
edsdoj.0d6b6a03b8594f6b8edc2680663aaf8a
Document Type :
article
Full Text :
https://doi.org/10.3390/transplantology3040029