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Metabolic Syndrome and Psoriasis: Pivotal Roles of Chronic Inflammation and Gut Microbiota

Authors :
Paola Secchiero
Erika Rimondi
Annalisa Marcuzzi
Giovanna Longo
Chiara Papi
Marta Manfredini
Matteo Fields
Lorenzo Caruso
Roberta Di Caprio
Anna Balato
Source :
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8098 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

In recent years, the incidence of metabolic syndrome (MS) has increased due to lifestyle-related factors in developed countries. MS represents a group of conditions that increase the risk of diabetes, cardiovascular diseases, and other severe health problems. Low-grade chronic inflammation is now considered one of the key aspects of MS and could be defined as a new cardiovascular risk factor. Indeed, an increase in visceral adipose tissue, typical of obesity, contributes to the development of an inflammatory state, which, in turn, induces the production of several proinflammatory cytokines responsible for insulin resistance. Psoriasis is a chronic relapsing inflammatory skin disease and is characterized by the increased release of pro-inflammatory cytokines, which can contribute to different pathological conditions within the spectrum of MS. A link between metabolic disorders and Psoriasis has emerged from evidence indicating that weight loss obtained through healthy diets and exercise was able to improve the clinical course and therapeutic response of Psoriasis in patients with obesity or overweight patients and even prevent its occurrence. A key factor in this balance is the gut microbiota; it is an extremely dynamic system, and this makes its manipulation through diet possible via probiotic, prebiotic, and symbiotic compounds. Given this, the gut microbiota represents an additional therapeutic target that can improve metabolism in different clinical conditions.

Details

Language :
English
ISSN :
14220067 and 16616596
Volume :
25
Issue :
15
Database :
Directory of Open Access Journals
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.0c960896e5ab4f5591a29d72c8d42683
Document Type :
article
Full Text :
https://doi.org/10.3390/ijms25158098