Identification of proteomic markers for metastasis of ovarian cancer

Authors :: V. E. Shevchenko
D. E. Makarov
S. V. Kovalev
N. E. Arnotskaya
N. R. Pogosyan
K. I. Zhordania
Source :: Опухоли женской репродуктивной системы, Vol 0, Iss 4, Pp 76-83 (2014)
Publication Year :: 2014
Publisher :: ABV-press, 2014.
Abstract: The proteome of ascites and pleural fluids (AF and PF) was mapped in patients with ovarian cancer (OC). 240 and 190 proteins were identi- fied with a high degree of assurance in A F and PF, respectively . The major portion w as extracellular and membrane proteins, whi ch ac- counted for 45 and 49 % in AF and PF, respectively. Analysis of the proteomic maps of AF and PF indicated that 82 proteins were common to these biological fluids whereas 81 and 49 proteins were unique to A F and PF, respectively. A list of 46 potential markers for O C metastasis and potential markers for tropic OC metastasis over the peritoneal (17 proteins) and pleural (11 proteins) surfaces is given.