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Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- Therapeutic modulation of the complement system has gained interest over the past two decades. Here, the authors provide molecular-level insight into the mode-of-action, target selectivity and species specificity of the compstatin family of complement inhibitors, which entered the clinic in 2021.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723 and 95879560
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0c7331cff4f34721b958795607a6055b
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-33003-7