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A tumor-specific endogenous repetitive element is induced by herpesviruses

Authors :
Maciej T. Nogalski
Alexander Solovyov
Anupriya S. Kulkarni
Niyati Desai
Adam Oberstein
Arnold J. Levine
David T. Ting
Thomas Shenk
Benjamin D. Greenbaum
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

The human genome includes a large amount of repetitive sequence, such as human satellite II (HSATII), but their function remains largely unknown. Here, Nogalski et al. show that herpesvirus infection induces HSATII RNA expression, which in turn affects virus replication and cell motility.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.0c0a14c407d84879b5ec6d1592ca8488
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-07944-x