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The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation

Authors :
Ho-Soo Lee
Zhonghui Lin
Sunyoung Chae
Young-Suk Yoo
Byung-Gyu Kim
Youngsoo Lee
Jared L. Johnson
You-Sun Kim
Lewis C. Cantley
Chang-Woo Lee
Hongtao Yu
Hyeseong Cho
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

The chromatin remodeler RSF1 is enriched at mitotic centromeres but its function there is poorly understood. Here, the authors show that RSF1 regulates H2A phosphorylation and acetylation at mitotic centromeres and contributes to chromosome stability.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.0bf89570019f4e5fb76ec6c3b0d31610
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-06377-w