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Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the PREDIMED Study

Authors :
Ana Garcia-Arellano
Raul Ramallal
Miguel Ruiz-Canela
Jordi Salas-Salvadó
Dolores Corella
Nitin Shivappa
Helmut Schröder
James R. Hébert
Emilio Ros
Enrique Gómez-Garcia
Ramon Estruch
José Lapetra
Fernando Arós
Miquel Fiol
Lluis Serra-Majem
Xavier Pintó
Nancy Babio
José I. González
Montse Fitó
J. Alfredo Martínez
Miguel A. Martínez-González
the PREDIMED investigators
Source :
Nutrients, Vol 7, Iss 6, Pp 4124-4138 (2015)
Publication Year :
2015
Publisher :
MDPI AG, 2015.

Abstract

Previous studies have reported an association between a more pro-inflammatory diet profile and various chronic metabolic diseases. The Dietary Inflammatory Index (DII) was used to assess the inflammatory potential of nutrients and foods in the context of a dietary pattern. We prospectively examined the association between the DII and the incidence of cardiovascular disease (CVD: myocardial infarction, stroke or cardiovascular death) in the PREDIMED (Prevención con Dieta Mediterránea) study including 7216 high-risk participants. The DII was computed based on a validated 137-item food frequency questionnaire. Multivariate-adjusted hazard ratios (HR) and 95% confidence intervals of CVD risk were computed across quartiles of the DII where the lowest (most anti-inflammatory) quartile is the referent. Risk increased across the quartiles (i.e., with increasing inflammatory potential): HRquartile2 = 1.42 (95%CI = 0.97–2.09); HRquartile3 = 1.85 (1.27–2.71); and HRquartile4 = 1.73 (1.15–2.60). When fit as continuous the multiple-adjusted hazard ratio for each additional standard deviation of the DII was 1.22 (1.06–1.40). Our results provide direct prospective evidence that a pro-inflammatory diet is associated with a higher risk of cardiovascular clinical events.

Details

Language :
English
ISSN :
20726643
Volume :
7
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Nutrients
Publication Type :
Academic Journal
Accession number :
edsdoj.0be29fdcef3c468d83e73e589af8e4a3
Document Type :
article
Full Text :
https://doi.org/10.3390/nu7064124