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Dietary Supplementation of Antioxidant Compounds Prevents Light-Induced Retinal Damage in a Rat Model

Authors :
Rosario Amato
Alessio Canovai
Alberto Melecchi
Salvatore Pezzino
Roberta Corsaro
Massimo Dal Monte
Dario Rusciano
Paola Bagnoli
Maurizio Cammalleri
Source :
Biomedicines, Vol 9, Iss 9, p 1177 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Light-induced retinal damage (LD) is characterized by the accumulation of reactive oxygen species leading to oxidative stress and photoreceptor cell death. The use of natural antioxidants has emerged as promising approach for the prevention of LD. Among them, lutein and cyanidin-3-glucoside (C3G) have been shown to be particularly effective due to their antioxidant and anti-inflammatory activity. However, less is known about the possible efficacy of combining them in a multicomponent mixture. In a rat model of LD, Western blot analysis, immunohistochemistry and electroretinography were used to demonstrate that lutein and C3G in combination or in a multicomponent mixture can prevent oxidative stress, inflammation, gliotic and apoptotic responses thus protecting photoreceptor cells from death with higher efficacy than each component alone. Combined efficacy on dysfunctional electroretinogram was also demonstrated by ameliorated rod and cone photoreceptor responses. These findings suggest the rationale to formulate multicomponent blends which may optimize the partnering compounds bioactivity and bioavailability.

Details

Language :
English
ISSN :
22279059
Volume :
9
Issue :
9
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.0bc94128e88f4cb495132d564ac69d52
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines9091177