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Markers of arterial stiffness in a sample of Lebanese subjects with Grade I essential hypertension
- Source :
- SAGE Open Medicine, Vol 5 (2017)
- Publication Year :
- 2017
- Publisher :
- SAGE Publishing, 2017.
-
Abstract
- Objectives: Arterial stiffness is becoming a major global condition associated with an increased risk of cardiovascular problems and death. Several markers have been linked to arterial stiffness. Methods: To determine and evaluate these relations, anthropometric parameters (weight, height, and pulse rate), biochemical profile, and central and peripheral indices of arterial function were measured in 114 Lebanese subjects with Grade I essential hypertension. Results: Age was associated with a higher pulse wave velocity (p = .001), central systolic blood pressure (p = .013), central pulse pressure (p = .028), central augmentation index (p ≤ .0001) with a lower heart rate (p = .08), and glomerular filtration rate (p = .019). Pulse wave velocity was found to be higher in older subjects (>65 years) and correlated with higher body mass index (r = .85) independent of age. Aging also correlated with higher plasma glucose and alterations in calcium–phosphorus metabolism. Conclusion: Aging is associated with increased arterial stiffness which is reflected by an increase in the pulse wave velocity, augmentation index, central pulse pressure, and central systolic blood pressure with a reduction in heart rate. Also, a higher body mass index and a lower estimated glomerular filtration rate (< 60 mL/min/1.73 m 2 ) are associated with increased arterial stiffness while calcium and phosphorus metabolism may play a role by promoting vascular calcification.
- Subjects :
- Medicine (General)
R5-920
Subjects
Details
- Language :
- English
- ISSN :
- 20503121
- Volume :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- SAGE Open Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0bc24e4425d4fb0840f9509f6766183
- Document Type :
- article
- Full Text :
- https://doi.org/10.1177/2050312117712886