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Clinical behavior of recurrent pleomorphic adenoma in the palate: a systematic review
- Source :
- Acta Cirúrgica Brasileira, Vol 39 (2024)
- Publication Year :
- 2024
- Publisher :
- Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2024.
-
Abstract
- ABSTRACT Purpose: This systematic review analyzed the clinical behavior and odds of malignancy of the palatal recurrent pleomorphic adenomas. Methods: Systematic review of patients with recurrent pleomorphic adenoma arising in the palate. Database search: MEDLINE, Scopus, Web of Science, Cochrane, EMBASE, Virtual Health Library, Google Scholar, and OpenGrey. A binomial logistic regression was performed to assess the odds of detecting recurrence five, 10 and 20 years after the treatment of primary tumor. Results: Thirteen studies (n = 18 patients) out of 336 were included. The recurrent pleomorphic adenoma in palate was more common in females (61.6%), average age was 49 years old (range 9–73 years old). Four patients progressed to malignant transformation. The odds ratio (OR) of detecting a recurrence at 10 (OR = 5.57; 95% confidence interval – 95%CI 1.13–27.52), and 20 years (OR = 18.78; 95%CI 3.18–110.84) after treatment of primary pleomorphic adenoma was significantly higher than at one-year follow-up. Conclusions: The recurrence of pleomorphic adenoma in palate remains a rare event of late occurrence. It mainly affects middle-aged female and carries a risk of malignant transformation. Although uncommon, patients with palatal pleomorphic adenoma should be warned about the possibility of recurrence or malignant transformation of tumor at advanced ages.
- Subjects :
- Neoplasms
Adenoma, Pleomorphic
Salivary Glands
Recurrence
Surgery
RD1-811
Subjects
Details
- Language :
- English
- ISSN :
- 16782674
- Volume :
- 39
- Database :
- Directory of Open Access Journals
- Journal :
- Acta Cirúrgica Brasileira
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0b991a2db248bda4e6598d93f754cf
- Document Type :
- article
- Full Text :
- https://doi.org/10.1590/acb390824