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Amyotrophic Lateral Sclerosis in Long-COVID Scenario and the Therapeutic Potential of the Purinergic System in Neuromodulation

Authors :
Júlia Leão Batista Simões
Samantha Webler Eichler
Maria Luíza Raitz Siqueira
Geórgia de Carvalho Braga
Margarete Dulce Bagatini
Source :
Brain Sciences, Vol 14, Iss 2, p 180 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Amyotrophic lateral sclerosis (ALS) involves the degeneration of motor neurons and debilitating and possibly fatal symptoms. The COVID-19 pandemic directly affected the quality of life of this group, and the SARS-CoV-2 infection accelerated the present neuroinflammatory process. Furthermore, studies indicate that the infection may have led to the development of the pathology. Thus, the scenario after this pandemic presents “long-lasting COVID” as a disease that affects people who have been infected. From this perspective, studying the pathophysiology behind ALS associated with SARS-CoV-2 infection and possible supporting therapies becomes necessary when we understand the impact on the quality of life of these patients. Thus, the purinergic system was trained to demonstrate how its modulation can add to the treatment, reduce disease progression, and result in better prognoses. From our studies, we highlight the P2X7, P2X4, and A2AR receptors and how their activity can directly influence the ALS pathway.

Details

Language :
English
ISSN :
20763425
Volume :
14
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Brain Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.0b650bcc847af9058e615d802f118
Document Type :
article
Full Text :
https://doi.org/10.3390/brainsci14020180