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Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila

Authors :
Mélanie Gracia
Sophie Theis
Amsha Proag
Guillaume Gay
Corinne Benassayag
Magali Suzanne
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

Tissue folding is a critical process during developmental morphogenesis. Here, Gracia et al. use live imaging, laser ablation and in silico modelling to demonstrate that cells entering EMT generate orthogonal forces necessary to drive mesoderm invagination in Drosophila.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.0b5e52f5c518423d9d99a13ba0e0739d
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-10720-0