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Iridium-Catalyzed asymmetric reduction of α,β-Unsaturated nitriles with water
- Source :
- Green Synthesis and Catalysis, Vol 5, Iss 3, Pp 175-179 (2024)
- Publication Year :
- 2024
- Publisher :
- KeAi Communications Co. Ltd., 2024.
-
Abstract
- The nitrile compounds are present in a variety of biologically active natural products and pharmaceuticals, and the nitrile groups are versatile synthetic intermediates to other functionalized compounds. Herein, the asymmetric reduction of α, β-unsaturated nitriles with water as a hydrogen source is reported. The reaction is catalyzed by the complex of [Ir(COD)Cl]2 and (Ra, S)-Ph-Bn-SiPhox, and allows the preparation of useful enantioenriched chiral 3,3-disubstituted propionitriles with high optical purities in mild conditions.
Details
- Language :
- English
- ISSN :
- 26665549
- Volume :
- 5
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Green Synthesis and Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0b412ca095b42068fdf2f5d508553a5
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.gresc.2023.07.002