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ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- The authors showed that, in C. elegans, inhibition of translation or mTORC1 increases ATF-4 expression independently of ISR signalling. ATF-4 promotes longevity by increasing hydrogen sulfide production by the enzyme CTH-2.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0b2d369bb38048e0accd70b4ceb4ae16
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-28599-9