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Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study

Authors :
Praveen Sripad
Jessica Rosenberg
Frank Boers
Christian P. Filss
Norbert Galldiks
Karl-Josef Langen
Ralf Clauss
N. Jon Shah
Jürgen Dammers
Source :
Case Reports in Neurological Medicine, Vol 2020 (2020)
Publication Year :
2020
Publisher :
Wiley, 2020.

Abstract

In the past two decades, many studies have shown the paradoxical efficacy of zolpidem, a hypnotic used to induce sleep, in transiently alleviating various disorders of consciousness such as traumatic brain injury (TBI), dystonia, and Parkinson’s disease. The mechanism of action of this effect of zolpidem is of great research interest. In this case study, we use magnetoencephalography (MEG) to investigate a fully conscious, ex-coma patient who suffered from neurological difficulties for a few years due to traumatic brain injury. For a few years after injury, the patient was under medication with zolpidem that drastically improved his symptoms. MEG recordings taken before and after zolpidem showed a reduction in power in the theta-alpha (4–12 Hz) and lower beta (15–20 Hz) frequency bands. An increase in power after zolpidem intake was found in the higher beta/lower gamma (20–43 Hz) frequency band. Source level functional connectivity measured using weighted-phase lag index showed changes after zolpidem intake. Stronger connectivity between left frontal and temporal brain regions was observed. We report that zolpidem induces a change in MEG resting power and functional connectivity in the patient. MEG is an informative and sensitive tool to detect changes in brain activity for TBI.

Details

Language :
English
ISSN :
20906668 and 20906676
Volume :
2020
Database :
Directory of Open Access Journals
Journal :
Case Reports in Neurological Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.0af9a7653a884471a55704d530830d1b
Document Type :
article
Full Text :
https://doi.org/10.1155/2020/8597062