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Assessment of Esophageal Motility Disorders in Patients with Refractory Gastroesophageal Reflux Disease

Authors :
Asghar Bagherzadeh
Saeed Abdi
Mohammad Reza Zali
Shooka Mohammadi
Source :
Acta Medica Iranica, Vol 60, Iss 10 (2022)
Publication Year :
2022
Publisher :
Tehran University of Medical Sciences, 2022.

Abstract

There is insufficient data about esophageal body dysmotility in patients with refractory gastroesophageal reflux disease (RGERD) who have inadequate response to proton pump inhibitors (PPIs) treatment. This study aimed to assess esophageal motility disorder and reflux parameters among these patients by high-resolution manometry (HRM) and intraluminal impedance and pH (MII‐pH) monitoring after stopping PPI therapy. A retrospective study was conducted among 100 RGERD patients admitted to Taleghani Hospital (Tehran, Iran) during one year. More than half of them were males (55%). The mean age of patients was 47.10 ± 6.92 and 50% of them had ineffective esophageal motility (IEM). Middle, distal, and proximal esophageal pressure (MEP, DEP, and PEP), integrated relaxation pressure (IRP), lower esophageal sphincter (LES) basal pressure (LESP), distal contractile integral (DCI), large breaks, upper esophageal sphincter basal pressure (UESP), and LES length (LESL) in the patients with IEM were significantly lower than the patients with normal esophageal motility (P

Details

Language :
English
ISSN :
00446025 and 17359694
Volume :
60
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Acta Medica Iranica
Publication Type :
Academic Journal
Accession number :
edsdoj.0af4692c9904030b70b391252da2864
Document Type :
article