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Assessment of Esophageal Motility Disorders in Patients with Refractory Gastroesophageal Reflux Disease
- Source :
- Acta Medica Iranica, Vol 60, Iss 10 (2022)
- Publication Year :
- 2022
- Publisher :
- Tehran University of Medical Sciences, 2022.
-
Abstract
- There is insufficient data about esophageal body dysmotility in patients with refractory gastroesophageal reflux disease (RGERD) who have inadequate response to proton pump inhibitors (PPIs) treatment. This study aimed to assess esophageal motility disorder and reflux parameters among these patients by high-resolution manometry (HRM) and intraluminal impedance and pH (MII‐pH) monitoring after stopping PPI therapy. A retrospective study was conducted among 100 RGERD patients admitted to Taleghani Hospital (Tehran, Iran) during one year. More than half of them were males (55%). The mean age of patients was 47.10 ± 6.92 and 50% of them had ineffective esophageal motility (IEM). Middle, distal, and proximal esophageal pressure (MEP, DEP, and PEP), integrated relaxation pressure (IRP), lower esophageal sphincter (LES) basal pressure (LESP), distal contractile integral (DCI), large breaks, upper esophageal sphincter basal pressure (UESP), and LES length (LESL) in the patients with IEM were significantly lower than the patients with normal esophageal motility (P
- Subjects :
- RGERD
HRM
MII-pH monitoring
IEM
esophageal motility
Medicine (General)
R5-920
Subjects
Details
- Language :
- English
- ISSN :
- 00446025 and 17359694
- Volume :
- 60
- Issue :
- 10
- Database :
- Directory of Open Access Journals
- Journal :
- Acta Medica Iranica
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0af4692c9904030b70b391252da2864
- Document Type :
- article