Back to Search Start Over

Identification of SEC61G as a Diagnostic and Prognostic Biomarker in Oral Squamous Cell Carcinoma

Authors :
Shi-Long Zhang
Lei Chen
Lin-Lin Bu
Zi-Li Yu
Si-Rui Ma
Source :
Biomedicines, Vol 11, Iss 10, p 2718 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Oral squamous cell carcinoma (OSCC) is a heterogeneous malignancy originating from the oral mucosal epithelium. Detecting novel biomarkers can offer crucial information on disease aggressiveness and expected clinical outcomes for individual patients. SEC61G, an aberrantly expressed gene in various cancers, has been associated with negative clinical outcomes. However, its expression and clinical significance in OSCC is still unclear. In the present study, we investigated the SEC61G expression level in OSCC using bioinformatic and immunohistochemical analyses. Additionally, our findings revealed a significant correlation between SEC61G expression and clinicopathological characteristics, as well as a worse prognosis in OSCC patients. Notably, flow cytometry analysis on patient samples revealed that SEC61G expression was also linked to decreased immune infiltration in OSCC patients. In conclusion, our study provides evidence supporting SEC61G’s role as a potential diagnostic, prognostic, and therapeutic marker in OSCC.

Details

Language :
English
ISSN :
22279059
Volume :
11
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.0ad9995ea3b84cb6bcc86d54d5cf5cba
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines11102718