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Dual-catalytic CuTPP/TiO2 nanoparticles for surface catalysis engineering of cardiovascular materials
- Source :
- Materials Today Bio, Vol 17, Iss , Pp 100494- (2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- Endowing materials with catalytic activities analogous to those of the natural endothelium to thus enhance their biological performance has become an option for constructing advanced blood-contact materials. The electron transfer between Cu2+ and Cu+ in the porphyrin center can catalyze the reaction of GSH and GSNO to generate NO, and this electron transfer can also catalyze the decomposition of ROS. Based on this, we created a dual-catalytic surface possessing NO-generating and ROS-scavenging activities to better mimic the versatile catalytic abilities of the endothelium. Copper tetraphenylporphyrin/titanium dioxide nanoparticles (CuTPP/TiO2-NPs) exhibiting excellent NO-generating and ROS-scavenging activities were synthesized and immobilized on the material surface to form a dual-catalytic film (CuTPP/TiO2-film) with the help of the catechol chemistry technique. Unlike most single catalytic surfaces, the dual-catalytic CuTPP/TiO2-film effectively regulated the microenvironment surrounding the implanted device by releasing NO signaling molecules and scavenging harmful ROS. This dual-catalytic film exhibited excellent biosafety and biocompatibility with anti-thrombosis, vascular wall cells (ECs and SMCs) modulation, and anti-inflammatory properties. We envision that this dual-catalytic endothelial bionic strategy may provide a promising solution to the clinical problems plaguing blood-contact devices and provide a novel basis for the further development of surface catalytic-engineered biomaterials.
Details
- Language :
- English
- ISSN :
- 25900064
- Volume :
- 17
- Issue :
- 100494-
- Database :
- Directory of Open Access Journals
- Journal :
- Materials Today Bio
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0ad3125279534ef094e96fec510f6c40
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.mtbio.2022.100494