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Identification of novel cytokine to judge the diagnosis and clinical phenotype of adult-onset Still’s disease

Authors :
Shuhei Yoshida
Yuya Fujita
Tomohiro Koga
Haruki Matsumoto
Yuya Sumichika
Kenji Saito
Shuzo Sato
Tomoyuki Asano
Masao Kobayakawa
Masashi Mizokami
Masaya Sugiyama
Kiyoshi Migita
Source :
Immunological Medicine, Pp 1-12 (2024)
Publication Year :
2024
Publisher :
Taylor & Francis Group, 2024.

Abstract

This study aimed to identify biomarkers to distinguish adult-onset Still’s disease (AOSD) and to predict disease phenotypes. In total, 49 patients diagnosed with AOSD and 200 patients with common diseases (controls) were included in the analysis. The levels of 69 cytokines were analyzed using a multi-suspension cytokine array. Cytokine cluster analysis was performed to identify specific molecular networks. Furthermore, random forest analysis and logistic regression analysis were used to rank cytokines based on their importance and to determine specific biomarkers for identification of AOSD patients and phenotypes. Patients with AOSD demonstrated significantly higher macrophage migration inhibitory factor (MIF) and interleukin (IL)-12(p40) serum levels than controls and patients with rheumatoid arthritis. Serum levels of chemokine (C-C motif) ligand (CCL) 8 and CCL22 were significantly lower in AOSD patients with a polycyclic systemic disease phenotype and could be differentiated with high accuracy from the other phenotypes (cutoff value for CCL8 = 122.7 pg/mL, CCL22 = 593.3 pg/mL, sensitivity 66.7%, specificity 87.1%, area under the curve 0.843). Combined MIF and IL-12(p40) levels may represent a biomarker for differentiating patients with AOSD from those with other diseases. The chemokine profiles of AOSD with a polycyclic systemic disease phenotype may differ from other phenotypes.

Details

Language :
English
ISSN :
25785826
Database :
Directory of Open Access Journals
Journal :
Immunological Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.0acb55495150446ba992b8fd8d446a46
Document Type :
article
Full Text :
https://doi.org/10.1080/25785826.2024.2411094