Back to Search Start Over

A Spanish Consensus on the Use of Safinamide for Parkinson’s Disease in Clinical Practice

Authors :
Javier Pagonabarraga
José Matías Arbelo
Francisco Grandas
Maria-Rosario Luquin
Pablo Martínez Martín
Mari Cruz Rodríguez-Oroz
Francesc Valldeoriola
Jaime Kulisevsky
Source :
Brain Sciences, Vol 10, Iss 3, p 176 (2020)
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

Safinamide is an approved drug for the treatment of motor fluctuations in Parkinson’s disease (PD). Scarce data are available on its use in clinical practice. A group of Spanish movement disorders specialists was convened to review the use of safinamide across different clinical scenarios that may guide neurologists in clinical practice. Eight specialists with recognized expertise in PD management elaborated the statements based on available evidence in the literature and on their clinical experience. The RAND/UCLA method was carried, with final conclusions accepted after a 2-round modified Delphi process. Higher level of agreement between panellists was reached for the following statements. Safinamide significantly improves mean daily OFF time without troublesome dyskinesias. Adjunctive treatment with safinamide is associated with motor improvements in patients with mid-to-late PD. The efficacy of safinamide on motor fluctuations is maintained at long-term, with no increase over time in dyskinesias severity. The clinical benefits of safinamide on pain and depression remain unclear. Safinamide presents a similar incidence of adverse events compared with placebo. The efficacy and safety of safinamide shown in the pivotal clinical trials are reproduced in clinical practice, with improvement of parkinsonian symptoms, decrease of daily OFF time, control of dyskinesias at the long term, and good tolerability and safety.

Details

Language :
English
ISSN :
20763425
Volume :
10
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Brain Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.0a99cea1e0de4a0d9eeb8bd90dfc5328
Document Type :
article
Full Text :
https://doi.org/10.3390/brainsci10030176