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A concise enantioselective synthesis of the guaiane sesquiterpene (−)-oxyphyllol
- Source :
- Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 2028-2032 (2013)
- Publication Year :
- 2013
- Publisher :
- Beilstein-Institut, 2013.
-
Abstract
- (−)-Oxyphyllol was prepared in only 4 steps from an epoxy enone that already served as an intermediate for the total synthesis of the anticancer guaiane (−)-englerin A. A regio- and diastereoselective Co(II)-catalyzed hydration of the olefin and a transannular epoxide opening were used as the key reactions.
Details
- Language :
- English
- ISSN :
- 18605397
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Beilstein Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0a009a4f0f4c4bd4b9c56f838cdb1fe0
- Document Type :
- article
- Full Text :
- https://doi.org/10.3762/bjoc.9.239