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Physician-initiated clinical study of limb ulcers treated with a functional peptide, SR-0379: from discovery to a randomized, double-blind, placebo-controlled trial
- Source :
- npj Aging and Mechanisms of Disease, Vol 4, Iss 1, Pp 1-7 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- Dermatology: peptide drug development for skin ulcers Chronic leg ulcers result in substantial impairment of patient quality of life with a socioeconomic impact both in terms of medical care and missed work days. A teams led by Hironori Nakagami at Osaka University originally identified a functional peptide, SR-0379, and evaluated the safety and efficacy of SR-0379 for the treatment of leg ulcers in a physician-initiated, first-in-patient, a multi-center, double-blind, randomized clinical study. In the evaluation of efficiency, the skin ulcer reduction rates were improved for the SR-0379 treated groups in a dose-dependent manner, compared for the placebo group with no causal adverse events. Since treatment with SR-0379 for chronic leg ulcers was safe, well tolerated, and effective in this initial clinical trial, the clinical trial on next stage will be designed toward peptide drug development.
- Subjects :
- Geriatrics
RC952-954.6
Subjects
Details
- Language :
- English
- ISSN :
- 20563973
- Volume :
- 4
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- npj Aging and Mechanisms of Disease
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.09f00e2134493984d4d6d63a79dba6
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41514-018-0021-7